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Karyopharm Therapeutics

Pioneering cancer therapies through extraordinary science and patient-driven innovation.

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Biotechnology
Founded 2008
Newton, MA
300
Profile last updated: August 2026

About Karyopharm Therapeutics

BiotechnologyFounded 2008

Karyopharm Therapeutics is driven by the extraordinary strength and courage of the patients we serve. What began as a visionary, founder-led start-up has evolved into a global leader in oncology innovation committed to transforming cancer treatment with bold, cutting-edge therapies. Our pioneering SINE (Selective Inhibition of Nuclear Export) technology targets cancer cells in a revolutionary way, offering hope for patients with both blood cancers and solid tumors. Headquartered in Newton, Massachusetts, we’ve expanded our global presence with our first FDA approved product now available across the U.S., Europe and Asia. Building on our success in multiple myeloma, Karyopharm is advancing a promising clinical pipeline that extends beyond oncology, with innovative compounds also targeting rare diseases. As we continue leading in oncology innovation, we are not just about advancing science; we are inspired daily by the patients we serve and fueled by the energy and resilience required to face challenges head-on. From our beginnings rooted in remarkable science to our position as a commercial-stage leader, Karyopharm is shaping a future that aims to redefine cancer care and improve lives.

Quick Facts

  • IndustryBiotechnology
  • Founded2008
  • HeadquartersNewton, MA
  • Certifications8

What Sets Us Apart

Patient-Centric Mission

Driven by the extraordinary strength and courage of patients we serve, every decision and innovation is inspired by those fighting cancer. Our purpose extends beyond science to meaningful impact on lives.

Pioneering Innovation Culture

From visionary founder-led origins to global oncology leadership, we embrace bold, cutting-edge breakthroughs. Our revolutionary SINE technology demonstrates our commitment to reimagining what's possible in cancer treatment.

Global Impact with Local Energy

Operating across the U.S., Europe, and Asia with FDA-approved products, we channel resilience and courage into facing challenges head-on while expanding our pipeline to rare diseases and beyond oncology.

Our Culture

The lived experience at Karyopharm Therapeutics

Patient-Driven Passion

Every day, employees connect their work to real patients fighting cancer. This patient-centric lens infuses decision-making, celebrates milestones, and reminds teams why their dedication matters—transforming scientific work into a mission with profound human impact.

Collaborative Trust

Cross-functional teams work seamlessly together without silos, built on a foundation of genuine trust from leadership. Colleagues support each other through challenges, celebrate collective wins, and bring diverse expertise to solve complex problems collaboratively.

Courageous Innovation

Employees are empowered to take calculated risks, challenge the status quo, and pursue bold scientific ideas. The culture celebrates both breakthrough successes and learning from setbacks, fostering an environment where groundbreaking discoveries flourish.

Flexibility & Autonomy

Work happens where people do their best thinking—onsite, at home, or anywhere in between. This trust-based flexibility reflects respect for individual working styles and life circumstances, allowing talented people to bring their full selves to their work.

Resilient Adaptability

The team navigates the inherent uncertainties of drug development with resilience and forward momentum. Obstacles become learning opportunities, setbacks fuel renewed determination, and the organization celebrates the grit required to pioneer life-changing therapies.

Our Culture DNA

The core values that drive Karyopharm Therapeutics

patientscourageinnovationcollaborationtrustresilienceflexibilitymission-drivenaccountabilityexcellencealignmentbreakthroughextraordinarysupportscientific

Frequently Asked Questions about Karyopharm Therapeutics

Common questions about working at Karyopharm Therapeutics, their culture, and benefits.

SINE (Selective Inhibition of Nuclear Export) is Karyopharm's proprietary technology platform that targets cancer cells in a revolutionary way. Our SINE compounds work by binding with and inhibiting XPO1, a nuclear export protein, which leads to the accumulation of tumor-suppressor proteins in cancer cells, effectively killing them while offering hope for patients with both blood cancers and solid tumors.

Karyopharm believes in trusting employees to work in whatever way lets them be their best selves—whether that's onsite, from home, or anywhere in between. Our flexible work arrangements reflect our commitment to supporting each person's unique needs and work style while maintaining our collaborative mission of delivering medicine for cancer.

We offer comprehensive wellness programs including weekly fitness classes, meditation programs, nutritional guidance, comprehensive health insurance coverage, and access to Care.com for family care management. Additionally, our Access Perks program provides exclusive discounts on fitness, sports, and wellness-related products and services.

Our culture is centered on three core principles: patients drive our passion, support and flexibility enable our best work, and our shared mission unites us. We've built an environment where exceptional people trust each other, collaborate across functions, and bring both focus and heart to the critical work of pioneering novel cancer therapies.

Karyopharm offers diverse career opportunities across clinical research, regulatory affairs, operations, research sciences, business development, and corporate functions. We hire exceptional people who are passionate about transforming cancer treatment and are committed to providing mentorship and professional development to support career growth.

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This profile is based on data from LinkedIn, Glassdoor, Indeed, and the company's public career page. All certifications are independently verified by Best Practice Institute.