Scientist, Genome Engineering

Dallas, TX

Research & Development

About the Role

At Colossal Biosciences in the Biotechnology space, Restoring Earth's extinct species through cutting-edge genetic engineering and de-extinction science..

<p>An affiliate of Colossal is hiring a Scientist to develop and implement genome engineering strategies for non-model mammalian organisms. The candidate will design and produce reagents for CRISPR/Cas9, prime editing, base editing, and additional modalities as needed; develop strategies for multiplex genome editing coupled with comprehensive genotyping assays; and independently analyze editing outcomes using appropriate bioinformatics tools. This hands-on role requires a scientist with established technical expertise who can contribute immediately, innovate, and collaborate closely with Cell Engineering teams responsible for cellular delivery and production of edited cell lines.</p>

<p>This position is based on-site in Dallas, TX. Relocation assistance is available.</p>

<h3><strong>Duties and Responsibilities:</strong></h3>

<ul>

<li>Design, execute, and optimize CRISPR/Cas9, prime editing, and base editing strategies, including multiplex editing of multiple genomic targets.</li>

<li>Design and generate guide RNAs, pegRNAs, donor templates, expression constructs, and other genome editing reagents; oversee their validation and quality control.</li>

<li>Innovate and troubleshoot editing strategies to improve efficiency, specificity, reproducibility, and scalability in non-model mammalian systems.</li>

<li>Apply knowledge of molecular genetics and DNA repair pathways to guide editing strategy, reagent design, troubleshooting, and interpretation of complex editing outcomes.</li>

<li>Independently design comprehensive genotyping assays to confirm intended edits, quantify editing efficiencies, and identify unintended or complex editing outcomes.</li>

<li>Analyze long- and short-read next-generation sequencing data using appropriate bioinformatics tools and pipelines; interpret allelic outcomes and use results to guide experimental decisions.</li>

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What It's Like to Work at Colossal Biosciences

Systemic Collaboration

Colossal Biosciences’s positive vision for the future is rooted in our unwavering commitment to the mission of Colossal. Fueled by cutting-edge technologies in biosciences and genetics, our employees are confident in our ability to lead in the fields of de-extinction and conservation. Our optimism is not just aspirational; it’s grounded in tangible progress. In essence, our employees share a deep belief that our efforts will make a lasting impact on the world, contributing to a healthier and more sustainable planet for generations to come.

Positive Vision for the Future

Our values aren’t just words; they are the driving force behind a united effort for a healthier planet. It’s a calling for our employees to make a tangible difference for endangered species, delicate ecosystems, and the balance of nature. Our workforce finds purpose in being pioneers of the Earth, ensuring a sustainable and thriving future. Our values aren’t just words; they are the driving force behind a united effort for a healthier planet.

Alignment of Values

Ben Lamm, our CEO, embodies Colossal Biosciences values by showcasing an exceptional commitment to innovation, ethics, and environmental responsibility. His visionary leadership in the field of de-extinction has propelled Colossal to the forefront of global impact and innovation. With a deep understanding of the market and a fearless venture into complex industries, Ben anticipates organizational needs and exemplifies superior ethical conduct. His dedication to preventing the ongoing extinction event sets him apart as a visionary leader, challenging traditional conservation efforts. Beyond Colossal, Ben’s involvement in emerging technologies, space, and climate change communities, as well as memberships in prestigious organizations like the Explorer’s Club and the Planetary Society, reflects a holistic approach. His thought leadership, recognized in prominent publications, underscores his influence in innovation, technology, and entrepreneurship, aligning seamlessly with Colossal’s commitment to pushing the boundaries of what is possible.

Respect

At Colossal, we prioritize an inclusive and respectful workplace. Our open-door leadership policy encourages diverse opinions, supported by various communication channels like Slack and share-out meetings. We actively promote anonymous feedback to ensure transparency, and company-wide surveys and check-ins with HR enable employees to shape our organization collaboratively. Our commitment to respect and inclusivity is a vital part of our culture, driving innovation through our diverse team.

Killer Outcomes

At Colossal, collaboration thrives through diverse channels. Brainstorming sessions drive creative problem-solving, while monthly happy hours foster interpersonal connections. Our journal club delves into the latest scientific literature, promoting cross-disciplinary dialogue. Active Slack channels facilitate real-time communication, ensuring seamless collaboration. Monthly Lunch and Learn sessions enrich our collective knowledge base. From formal meetings to informal gatherings, our multifaceted approach ensures a dynamic and connected work environment, essential for advancing our groundbreaking work to restore earth to a healthier state.

What It's Like to Work Here

Zap Bold Innovation in Action

Heart Purpose-Driven Impact

Users Seamless Collaboration Across Disciplines

Brain Continuous Learning From World Leaders

TreePine Radical Responsibility for Earth's Future

Frequently Asked Questions About Working at Colossal Biosciences

Common questions candidates ask about this role and Colossal Biosciences's workplace

Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth. The company is the first to apply CRISPR technology for the purposes of species de-extinction, beginning with the woolly mammoth. Colossal is accepting humanity’s duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies.

Please review the specific job listing or contact Colossal Biosciences's recruiting team for details on remote or hybrid work options for this role.

Salary information may vary by role and location. Please check the specific job listing or discuss compensation during the interview process.

Colossal Biosciences is an established organization in its industry. The company focuses on maintaining a supportive workplace culture for all employees.

Key benefit categories include: Health & Wellness, Workplace Perks, Professional Development. You can view more details on their CertCheck profile.

The day-to-day environment is guided by core values such as Bold Innovation in Action and Purpose-Driven Impact and Seamless Collaboration Across Disciplines.

The company has committed to inclusive practices including: Mission-Driven Purpose and Transparent Visionary Leadership.

They score particularly well in the area of Systemic Collaboration.

Colossal Biosciences currently has 15 open positions. They are hiring across departments like Animal Operations, Exogenous Development, Corporate. You can view all current openings at certcheck.mostlovedworkplace.com/companies/colossal-biosciences/jobs.

The interview process typically involves an initial recruiter screen followed by team interviews. Please contact Colossal Biosciences's recruiting team for specific details on this role's process.